Ferritin Human Liver Partially Purified
Ferritin is a large multi-subunit protein whose main function is to store iron, thus creating a reservoir that the body can use for its multiple requirements. After hemoglobin, the vast majority of iron in the body is stored in the crystalline core of ferritin. While ferritin can be found in all tissues of the body, it’s primarily found in the liver, spleen and bone marrow1. Holoferritin is the term used to refer to ferritin fully loaded with iron, whereas apoferritin refers to the protein alone. A partially degraded form of ferritin is known as hemosiderin.
The main biological function of ferritin is to help regulate iron homeostasis. Consequently, testing serum ferritin can provide useful information on a patient’s iron status. Other tests which aid in understanding a patient’s iron status include: total serum iron, total iron binding capacity (TIBC), unsaturated iron binding capacity (UIBC), and the iron transport protein, transferrin2-9. Ferritin is a versatile clinical analyte and has applications aside from its role as an indicator of iron status. Some examples include the diagnosis of Still’s Disease10, and the prognosis and management of various cancers such as neuroblastoma11,12, Hodgkin’s Disease13, lung cancer14 and laryngeal cancer15.
|ADULT TOTAL FERRITIN REFERENCE RANGE1:
||20-250 ng/mL (male)
||10-120 ng/mL (female)
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