Myoglobin
Myoglobin is an iron and oxygen-binding protein found in the muscle tissue, predominantly in the heart, and is responsible for oxygen storage in the muscle.
| Product Specifications | |
|---|---|
| Source | Human Heart |
| Form | Liquid |
| Buffer | TRIS buffer with 0.1% Sodium Azide at pH 7.5 |
| Concentration | ≥1 mg/mL |
| Purity | Immunopure is ≥ 95% by SDS Page |
| Storage | 2-8°C |
| Molecular Weight | 16.7 - 17.7 kDa |
| Appearance | Clear, red to amber in color |
It is the primary oxygen-carrying pigment of muscle tissues. In humans, it is abnormal to find Myoglobin in the bloodstream. Therefore, if a patient’s blood diagnostic tests for Myoglobin, it is diagnostically relevant and could indicate a muscle injury. Myoglobin was the first protein to have its three dimensional structure revealed by X-ray crystallography. Although both bind oxygen to the heme group, the difference between Myoglobin and Hemoglobin is the Myoglobin has a a higher affinity for oxygen. Hemoglobin transports oxygen, whereas Myoglobin stores oxygen. An increase level of Myoglobin does not determine an acute myocardial infarction (AMI). However, Myoglobin is still an important analyte on a cardiac panel due to its excellent sensitivity and it gets released earlier than the other major cardiac markers. It is useful in aiding the diagnosis (rule-out) and for the prognosis of an AMI.
