NGAL – Neutrophil Gelatinase-Associated Lipocalin
Neutrophil Gelatinase-Associated Lipocalin is a 25 kDa protein and as its name suggests, the protein in neutrophils is often found bound to gelatinase-B (also known as matrix metalloproteinase-9)
|Analytes||Neutrophil Gelatinase-Associated Lipocalin (NGAL)|
|Shelf Life||17 Months|
|Reconstituted or Open Vial Stability*||30 Days|
|Typical Fill Sizes|
NGAL is also known as lipocalin-2. Lipocalins are proteins that bind and transport various substances. While the physiological role of NGAL is not fully understood, it is thought to play a role in the response to bacterial infection by sequestering iron and thus making it less available to invading pathogens.
Acute kidney injury (AKI) is a condition in which rapid decline of kidney function is observed. Although there is not a universally agreed upon definition of AKI, it is a very common problem, being reported in up to 0.5% of the general population, depending on the definition used. AKI is difficult to diagnose since symptoms and elevated levels of markers of renal function (eg: creatinine) generally do not occur until the injury is quite advanced. NGAL in both plasma and urine appears to be a marker that is very well suited for the early detection of AKI and could be instrumental in improving the diagnosis and prognosis of this condition.